Does serum prostate specific antigen levels correlate with the prostatic inflammation in elderly patients without clinically proven prostate cancer?

Objectives: To determine the whether histological prostatic inflammation correlates with serum prostate specific antigen (PSA), free PSA (fPSA) and percent of fPSA (%fPSA) levels in elderly patients without clinically proven cancer. Methods: A total 115 cancer transrectal biopsy were included this retrospective study. Patients divided two main groups as histologic inflammation. grading was performed into three subgroups. The age, volume, PSA, %fPSA compared between Correlation parameters grade also investigated. Results: Serum significantly higher men histologically (15.47 ± 15.28 ng/mL vs. 11.67 8.12 ng/mL; p = 0.002 19.8 0.7 15.79 0.9; 0.01, respectively). mean different among subgroups (p 0.02) correlated positively (r 0.320, < 0.001). Conclusions: Our findings suggested that reporting may help avoiding unnecessary repeat biopsies if elevated level is only indication for initial biopsy.